Exhibitions include visual and performing arts and music events, with monthly public programs spanning a wide range of topics.  The Opening Gallery has presented international and US based artists including Andres Serrano, Sagarika Sundaram, Michele Zalopany, Kenneth Goldsmith, John Zorn, The Shoplifter, Luciano Chessa, Daniel Firman, Hans Weigand, Raúl Cordero, Jessica Mitrani, United Nations artist-observer Yann Toma, Warren Neidich, Coleman Collins, Constance DeJong, Charles Gaines, Jimmie Durham, Leslie Hewitt, Jimmy Raskin, Agnieszka Kurant, Olu Oguibe, Martha Rosler, Allen Ruppersberg, Chrysanne Stathacos, Leah Singer, Ronan Day-Lewis, Orit Ben Shitrit, and Bill Hayward. In spring 2024 the gallery program will present a selection of Watermill Center former artists-in-residence including Eileen O’ Kane Kornreich, Christopher Knowles with Sylvia Netzer, D. Graham Burnett and "The Order of the Third Bird," and Brian Block.

The Gallery has hosted the New York Arab Festival and events organized by MoMA curators and collaborates with Sorbonne Art Gallery in Paris. The nonprofit cultural venue and initiative supports an heteroclite art ecosystem that attempts to go beyond prevalent gallery models in Tribeca. Proceeds support neurodiversity, charitable causes, and the non-profit Luv Michael, which is committed to enriching the lives of autistic adults.

The Opening was founded by Sozita Goudouna, PhD and in 2023 partnered with the London-based publisher Eris to present exhibitions related to publications by Kenneth Goldsmith, Andres Serrano, ORLAN, Lucas Samaras, and Maurice Saatchi among other acclaimed contributors and artists. Our publishing art program has hosted readings of Edward Said's poems by Simon Critchley, Stathis Gourgouris, and Udi Aloni, as well as readings of Gabriele Tinti by Vincent Piazza.